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Uptake of Fluorescent Gentamicin by Peripheral Vestibular Cells after Systemic Administration

OBJECTIVE: In addition to cochleotoxicity, systemic aminoglycoside pharmacotherapy causes vestibulotoxicity resulting in imbalance and visual dysfunction. The underlying trafficking routes of systemically-administered aminoglycosides from the vasculature to the vestibular sensory hair cells are larg...

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Detalles Bibliográficos
Autores principales: Liu, Jianping, Kachelmeier, Allan, Dai, Chunfu, Li, Hongzhe, Steyger, Peter S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4368668/
https://www.ncbi.nlm.nih.gov/pubmed/25793391
http://dx.doi.org/10.1371/journal.pone.0120612