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Lipid Mixtures Containing a Very High Proportion of Saturated Fatty Acids Only Modestly Impair Insulin Signaling in Cultured Muscle Cells

In vitro examinations of the effect of saturated fatty acids on skeletal muscle insulin action often use only one or two different fatty acid species, which does not resemble the human plasma fatty acid profile. We compared graded concentrations (0.1-0.8mM) of 3 different lipid mixtures: 1) a physio...

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Detalles Bibliográficos
Autores principales: Newsom, Sean A., Everett, Allison C., Park, Sanghee, Van Pelt, Douglas W., Hinko, Alexander, Horowitz, Jeffrey F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4368748/
https://www.ncbi.nlm.nih.gov/pubmed/25793412
http://dx.doi.org/10.1371/journal.pone.0120871