Hypoxia-Sensitive Epigenetic Regulation of an Antisense-Oriented lncRNA Controls WT1 Expression in Myeloid Leukemia Cells

WT1 is a transcription factor expressed in hematopoietic stem cells and in most cases of myeloid leukemia. We investigated the roles of hypoxia and epigenetics in the regulation of WT1 expression in myeloid leukemia cells. WT1 expression correlates with hypomethylation of the CpG island in Intron 1,...

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Detalles Bibliográficos
Autores principales: McCarty, Gregory, Loeb, David M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4368825/
https://www.ncbi.nlm.nih.gov/pubmed/25794157
http://dx.doi.org/10.1371/journal.pone.0119837

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4368825/
https://www.ncbi.nlm.nih.gov/pubmed/25794157
http://dx.doi.org/10.1371/journal.pone.0119837

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