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BDNF Release Is Required for the Behavioral Actions of Ketamine

BACKGROUND: Recent studies demonstrate that the rapid antidepressant ketamine increases spine number and function in the medial prefrontal cortex (mPFC), and that these effects are dependent on activation of glutamate α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptors and brain-de...

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Detalles Bibliográficos
Autores principales: Lepack, Ashley E., Fuchikami, Manabu, Dwyer, Jason M., Banasr, Mounira, Duman, Ronald S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4368871/
https://www.ncbi.nlm.nih.gov/pubmed/25539510
http://dx.doi.org/10.1093/ijnp/pyu033