Preclinical to Clinical Translation of CNS Transporter Occupancy of TD-9855, a Novel Norepinephrine and Serotonin Reuptake Inhibitor

BACKGROUND: Monoamine reuptake inhibitors exhibit unique clinical profiles that reflect distinct engagement of the central nervous system (CNS) transporters. METHODS: We used a translational strategy, including rodent pharmacokinetic/pharmacodynamic modeling and positron emission tomography (PET) im...

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Detalles Bibliográficos
Autores principales: Smith, Jacqueline AM, Patil, DL, Daniels, OT, Ding, Y-S, Gallezot, J-D, Henry, S, Kim, KHS, Kshirsagar, S, Martin, WJ, Obedencio, GP, Stangeland, E, Tsuruda, PR, Williams, W, Carson, RE, Patil, ST
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4368888/
https://www.ncbi.nlm.nih.gov/pubmed/25522383
http://dx.doi.org/10.1093/ijnp/pyu027

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4368888/
https://www.ncbi.nlm.nih.gov/pubmed/25522383
http://dx.doi.org/10.1093/ijnp/pyu027

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