Ribosomal frameshifting in the CCR5 mRNA is regulated by miRNAs and the NMD pathway

Programmed −1 ribosomal frameshift (−1 PRF) signals redirect translating ribosomes to slip back one base on messenger RNAs. Although well characterized in viruses, how these elements may regulate cellular gene expression is not understood. Here we describe a −1 PRF signal in the human mRNA encoding...

Descripción completa

Detalles Bibliográficos
Autores principales: Belew, Ashton Trey, Meskauskas, Arturas, Musalgaonkar, Sharmishtha, Advani, Vivek M., Sulima, Sergey O., Kasprzak, Wojciech K., Shapiro, Bruce A., Dinman, Jonathan D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4369343/
https://www.ncbi.nlm.nih.gov/pubmed/25043019
http://dx.doi.org/10.1038/nature13429

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4369343/
https://www.ncbi.nlm.nih.gov/pubmed/25043019
http://dx.doi.org/10.1038/nature13429

Ejemplares similares