Deletion of Pim Kinases Elevates the Cellular Levels of Reactive Oxygen Species and Sensitizes to K-Ras-Induced Cell Killing

The Pim protein kinases contribute to transformation by enhancing the activity of oncogenic Myc and Ras, which drives significant metabolic changes during tumorigenesis. In this report, we demonstrate that mouse embryo fibroblasts (MEFs) lacking all three isoforms of Pim protein kinases, triple knoc...

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Detalles Bibliográficos
Autores principales: Song, Jin H., An, Ningfei, Chatterjee, Shilpak, Kistner-Griffin, Emily, Mahajan, Sandeep, Mehrotra, Shikhar, Kraft, Andrew S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4369476/
https://www.ncbi.nlm.nih.gov/pubmed/25241892
http://dx.doi.org/10.1038/onc.2014.306

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4369476/
https://www.ncbi.nlm.nih.gov/pubmed/25241892
http://dx.doi.org/10.1038/onc.2014.306

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