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Examining the freezing process of an intermediate bulk containing an industrially relevant protein

Numerous biopharmaceuticals are produced in recombinant microorganisms in the controlled environment of a bioreactor, a process known as Upstream Process. To minimize product loss due to physico-chemical and enzymatic degradation, the Upstream Process should be directly followed by product purificat...

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Detalles Bibliográficos
Autores principales: Reinsch, Holger, Spadiut, Oliver, Heidingsfelder, Johannes, Herwig, Christoph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4370381/
https://www.ncbi.nlm.nih.gov/pubmed/25765305
http://dx.doi.org/10.1016/j.enzmictec.2015.01.003