Genotype-Property Patient-Phenotype Relations Suggest that Proteome Exhaustion Can Cause Amyotrophic Lateral Sclerosis

Late-onset neurodegenerative diseases remain poorly understood as search continues for the perceived pathogenic protein species. Previously, variants in Superoxide Dismutase 1 (SOD1) causing Amyotrophic Lateral Sclerosis (ALS) were found to destabilize and reduce net charge, suggesting a pathogenic...

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Detalles Bibliográficos
Autor principal: Kepp, Kasper P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4370410/
https://www.ncbi.nlm.nih.gov/pubmed/25798606
http://dx.doi.org/10.1371/journal.pone.0118649

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4370410/
https://www.ncbi.nlm.nih.gov/pubmed/25798606
http://dx.doi.org/10.1371/journal.pone.0118649

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