Codon Optimization of the Human Papillomavirus E7 Oncogene Induces a CD8(+) T Cell Response to a Cryptic Epitope Not Harbored by Wild-Type E7

Codon optimization of nucleotide sequences is a widely used method to achieve high levels of transgene expression for basic and clinical research. Until now, immunological side effects have not been described. To trigger T cell responses against human papillomavirus, we incubated T cells with dendri...

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Detalles Bibliográficos
Autores principales: Lorenz, Felix K. M., Wilde, Susanne, Voigt, Katrin, Kieback, Elisa, Mosetter, Barbara, Schendel, Dolores J., Uckert, Wolfgang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4370481/
https://www.ncbi.nlm.nih.gov/pubmed/25799237
http://dx.doi.org/10.1371/journal.pone.0121633

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4370481/
https://www.ncbi.nlm.nih.gov/pubmed/25799237
http://dx.doi.org/10.1371/journal.pone.0121633

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