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Codon Optimization of the Human Papillomavirus E7 Oncogene Induces a CD8(+) T Cell Response to a Cryptic Epitope Not Harbored by Wild-Type E7
Codon optimization of nucleotide sequences is a widely used method to achieve high levels of transgene expression for basic and clinical research. Until now, immunological side effects have not been described. To trigger T cell responses against human papillomavirus, we incubated T cells with dendri...
Autores principales: | Lorenz, Felix K. M., Wilde, Susanne, Voigt, Katrin, Kieback, Elisa, Mosetter, Barbara, Schendel, Dolores J., Uckert, Wolfgang |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4370481/ https://www.ncbi.nlm.nih.gov/pubmed/25799237 http://dx.doi.org/10.1371/journal.pone.0121633 |
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