Stabilization of Resveratrol in Blood Circulation by Conjugation to mPEG and mPEG-PLA Polymers: Investigation of Conjugate Linker and Polymer Composition on Stability, Metabolism, Antioxidant Activity and Pharmacokinetic Profile

Resveratrol is naturally occurring phytochemical with diverse biological activities such as chemoprevention, anti-inflammatory, anti-cancer, anti-oxidant. But undergoes rapid metabolism in the body (half life 0.13h). Hence Polymer conjugation utilizing different chemical linkers and polymer composit...

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Detalles Bibliográficos
Autores principales: Siddalingappa, Basavaraj, Benson, Heather A. E., Brown, David H., Batty, Kevin T., Chen, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4370505/
https://www.ncbi.nlm.nih.gov/pubmed/25799413
http://dx.doi.org/10.1371/journal.pone.0118824

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4370505/
https://www.ncbi.nlm.nih.gov/pubmed/25799413
http://dx.doi.org/10.1371/journal.pone.0118824

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