Imbalance in Fatty-Acid-Chain Length of Gangliosides Triggers Alzheimer Amyloid Deposition in the Precuneus

Amyloid deposition, a crucial event of Alzheimer’s disease (AD), emerges in distinct brain regions. A key question is what triggers the assembly of the monomeric amyloid ß-protein (Aß) into fibrils in the regions. On the basis of our previous findings that gangliosides facilitate the initiation of A...

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Detalles Bibliográficos
Autores principales: Oikawa, Naoto, Matsubara, Teruhiko, Fukuda, Ryoto, Yasumori, Hanaki, Hatsuta, Hiroyuki, Murayama, Shigeo, Sato, Toshinori, Suzuki, Akemi, Yanagisawa, Katsuhiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4370507/
https://www.ncbi.nlm.nih.gov/pubmed/25798597
http://dx.doi.org/10.1371/journal.pone.0121356

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4370507/
https://www.ncbi.nlm.nih.gov/pubmed/25798597
http://dx.doi.org/10.1371/journal.pone.0121356

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