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p38 MAP Kinase Inhibitor Suppresses Transforming Growth Factor-β2–Induced Type 1 Collagen Production in Trabecular Meshwork Cells

Glaucoma is an age-related neurodegenerative disease of retinal ganglion cells, and appropriate turnover of the extracellular matrix in the trabecular meshwork is important in its pathology. Here, we report the effects of Rho-associated kinase (ROCK) and p38 MAP kinase on transforming growth factor...

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Detalles Bibliográficos
Autores principales: Inoue-Mochita, Miyuki, Inoue, Toshihiro, Fujimoto, Tomokazu, Kameda, Takanori, Awai-Kasaoka, Nanako, Ohtsu, Naoki, Kimoto, Kenichi, Tanihara, Hidenobu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4370581/
https://www.ncbi.nlm.nih.gov/pubmed/25799097
http://dx.doi.org/10.1371/journal.pone.0120774