The Human Cytomegalovirus UL133-138 Gene Locus Attenuates the Lytic Viral Cycle in Fibroblasts

The genomes of HCMV clinical strains (e.g. FIX, TR, PH, etc) contain a 15 kb region that encodes 20 putative ORFs. The region, termed ULb’, is lost after serial passage of virus in human foreskin fibroblast (HFF) cell culture. Compared to clinical strains, laboratory strains replicate faster and to...

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Detalles Bibliográficos
Autores principales: Dutta, Nirmal, Lashmit, Philip, Yuan, Jinxiang, Meier, Jeffery, Stinski, Mark F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4370700/
https://www.ncbi.nlm.nih.gov/pubmed/25799165
http://dx.doi.org/10.1371/journal.pone.0120946

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4370700/
https://www.ncbi.nlm.nih.gov/pubmed/25799165
http://dx.doi.org/10.1371/journal.pone.0120946

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