Scalable Production in Human Cells and Biochemical Characterization of Full-Length Normal and Mutant Huntingtin

Huntingtin (Htt) is a 350 kD intracellular protein, ubiquitously expressed and mainly localized in the cytoplasm. Huntington’s disease (HD) is caused by a CAG triplet amplification in exon 1 of the corresponding gene resulting in a polyglutamine (polyQ) expansion at the N-terminus of Htt. Production...

Descripción completa

Detalles Bibliográficos
Autores principales: Huang, Bin, Lucas, Tanja, Kueppers, Claudia, Dong, Xiaomin, Krause, Maike, Bepperling, Alexander, Buchner, Johannes, Voshol, Hans, Weiss, Andreas, Gerrits, Bertran, Kochanek, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4370734/
https://www.ncbi.nlm.nih.gov/pubmed/25799558
http://dx.doi.org/10.1371/journal.pone.0121055

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4370734/
https://www.ncbi.nlm.nih.gov/pubmed/25799558
http://dx.doi.org/10.1371/journal.pone.0121055

Ejemplares similares