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Scalable Production in Human Cells and Biochemical Characterization of Full-Length Normal and Mutant Huntingtin

Huntingtin (Htt) is a 350 kD intracellular protein, ubiquitously expressed and mainly localized in the cytoplasm. Huntington’s disease (HD) is caused by a CAG triplet amplification in exon 1 of the corresponding gene resulting in a polyglutamine (polyQ) expansion at the N-terminus of Htt. Production...

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Detalles Bibliográficos
Autores principales:	Huang, Bin, Lucas, Tanja, Kueppers, Claudia, Dong, Xiaomin, Krause, Maike, Bepperling, Alexander, Buchner, Johannes, Voshol, Hans, Weiss, Andreas, Gerrits, Bertran, Kochanek, Stefan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4370734/ https://www.ncbi.nlm.nih.gov/pubmed/25799558 http://dx.doi.org/10.1371/journal.pone.0121055

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