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Development of a Targeted Flip-in System in Avian DT40 Cells

Gene-targeting to create null mutants or designed-point mutants is a powerful tool for the molecular dissection of complex phenotypes involving DNA repair, signal transduction, and metabolism. Because gene-targeting is critically impaired in mutants exhibiting attenuated homologous recombination (HR...

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Detalles Bibliográficos
Autores principales: Kobayashi, Kaori, Fujii, Toshihiko, Asada, Ryuta, Ooka, Masato, Hirota, Kouji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4370768/
https://www.ncbi.nlm.nih.gov/pubmed/25799417
http://dx.doi.org/10.1371/journal.pone.0122006