Angiopoietin-like proteins stimulate HSPC development through interaction with notch receptor signaling

Angiopoietin-like proteins (angptls) are capable of ex vivo expansion of mouse and human hematopoietic stem and progenitor cells (HSPCs). Despite this intriguing ability, their mechanism is unknown. In this study, we show that angptl2 overexpression is sufficient to expand definitive HSPCs in zebraf...

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Detalles Bibliográficos
Autores principales: Lin, Michelle I, Price, Emily N, Boatman, Sonja, Hagedorn, Elliott J, Trompouki, Eirini, Satishchandran, Sruthi, Carspecken, Charles W, Uong, Audrey, DiBiase, Anthony, Yang, Song, Canver, Matthew C, Dahlberg, Ann, Lu, Zhigang, Zhang, Cheng Cheng, Orkin, Stuart H, Bernstein, Irwin D, Aster, Jon C, White, Richard M, Zon, Leonard I
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Developmental Biology and Stem Cells
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4371382/
https://www.ncbi.nlm.nih.gov/pubmed/25714926
http://dx.doi.org/10.7554/eLife.05544

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4371382/
https://www.ncbi.nlm.nih.gov/pubmed/25714926
http://dx.doi.org/10.7554/eLife.05544

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