A new classifier-based strategy for in-silico ion-channel cardiac drug safety assessment

There is currently a strong interest in using high-throughput in-vitro ion-channel screening data to make predictions regarding the cardiac toxicity potential of a new compound in both animal and human studies. A recent FDA think tank encourages the use of biophysical mathematical models of cardiac...

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Detalles Bibliográficos
Autores principales: Mistry, Hitesh B., Davies, Mark R., Di Veroli, Giovanni Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4371651/
https://www.ncbi.nlm.nih.gov/pubmed/25852560
http://dx.doi.org/10.3389/fphar.2015.00059

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4371651/
https://www.ncbi.nlm.nih.gov/pubmed/25852560
http://dx.doi.org/10.3389/fphar.2015.00059

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