Dimerization of cAMP phosphodiesterase-4 (PDE4) in living cells requires interfaces located in both the UCR1 and catalytic unit domains

PDE4 family cAMP phosphodiesterases play a pivotal role in determining compartmentalised cAMP signalling through targeted cAMP breakdown. Expressing the widely found PDE4D5 isoform, as both bait and prey in a yeast 2-hybrid system, we demonstrated interaction consistent with the notion that long PDE...

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Detalles Bibliográficos
Autores principales: Bolger, Graeme B., Dunlop, Allan J., Meng, Dong, Day, Jon P., Klussmann, Enno, Baillie, George S., Adams, David R., Houslay, Miles D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science Ltd 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4371794/
https://www.ncbi.nlm.nih.gov/pubmed/25546709
http://dx.doi.org/10.1016/j.cellsig.2014.12.009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4371794/
https://www.ncbi.nlm.nih.gov/pubmed/25546709
http://dx.doi.org/10.1016/j.cellsig.2014.12.009

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