Polycomb- and REST-associated histone deacetylases are independent pathways toward a mature neuronal phenotype

The bivalent hypothesis posits that genes encoding developmental regulators required for early lineage decisions are poised in stem/progenitor cells by the balance between a repressor histone modification (H3K27me3), mediated by the Polycomb Repressor Complex 2 (PRC2), and an activator modification...

Descripción completa

Detalles Bibliográficos
Autores principales: McGann, James C, Oyer, Jon A, Garg, Saurabh, Yao, Huilan, Liu, Jun, Feng, Xin, Liao, Lujian, Yates, John R, Mandel, Gail
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2014
Materias:
Developmental Biology and Stem Cells
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4371837/
https://www.ncbi.nlm.nih.gov/pubmed/25250711
http://dx.doi.org/10.7554/eLife.04235

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4371837/
https://www.ncbi.nlm.nih.gov/pubmed/25250711
http://dx.doi.org/10.7554/eLife.04235

Ejemplares similares