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Polycomb- and REST-associated histone deacetylases are independent pathways toward a mature neuronal phenotype

The bivalent hypothesis posits that genes encoding developmental regulators required for early lineage decisions are poised in stem/progenitor cells by the balance between a repressor histone modification (H3K27me3), mediated by the Polycomb Repressor Complex 2 (PRC2), and an activator modification...

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Detalles Bibliográficos
Autores principales:	McGann, James C, Oyer, Jon A, Garg, Saurabh, Yao, Huilan, Liu, Jun, Feng, Xin, Liao, Lujian, Yates, John R, Mandel, Gail
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2014
Materias:	Developmental Biology and Stem Cells
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4371837/ https://www.ncbi.nlm.nih.gov/pubmed/25250711 http://dx.doi.org/10.7554/eLife.04235

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