Cargando…

Inflammation-Induced Cell Proliferation Potentiates DNA Damage-Induced Mutations In Vivo

Mutations are a critical driver of cancer initiation. While extensive studies have focused on exposure-induced mutations, few studies have explored the importance of tissue physiology as a modulator of mutation susceptibility in vivo. Of particular interest is inflammation, a known cancer risk facto...

Descripción completa

Detalles Bibliográficos
Autores principales: Kiraly, Orsolya, Gong, Guanyu, Olipitz, Werner, Muthupalani, Sureshkumar, Engelward, Bevin P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4372043/
https://www.ncbi.nlm.nih.gov/pubmed/25647331
http://dx.doi.org/10.1371/journal.pgen.1004901