Characterization of a Brain Permeant Fluorescent Molecule and Visualization of Aβ Parenchymal Plaques, Using Real-Time Multiphoton Imaging in Transgenic Mice

[Image: see text] Emerging paradigms mandate discovery of imaging agents for diagnosing Alzheimer’s disease (AD) prior to appearance of clinical symptoms. To accomplish this objective, a novel heterocyclic molecule (4) was synthesized and validated as Aβ targeted probe. The agent shows labeling of n...

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Detalles Bibliográficos
Autores principales: Sundaram, G.S.M., Garai, Kanchan, Rath, Nigam P., Yan, Ping, Cirrito, John R., Cairns, Nigel J., Lee, Jin-Moo, Sharma, Vijay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4372081/
https://www.ncbi.nlm.nih.gov/pubmed/25003699
http://dx.doi.org/10.1021/ol501264q

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4372081/
https://www.ncbi.nlm.nih.gov/pubmed/25003699
http://dx.doi.org/10.1021/ol501264q

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