Characterization of a Brain Permeant Fluorescent Molecule and Visualization of Aβ Parenchymal Plaques, Using Real-Time Multiphoton Imaging in Transgenic Mice

[Image: see text] Emerging paradigms mandate discovery of imaging agents for diagnosing Alzheimer’s disease (AD) prior to appearance of clinical symptoms. To accomplish this objective, a novel heterocyclic molecule (4) was synthesized and validated as Aβ targeted probe. The agent shows labeling of n...

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Autores principales: Sundaram, G.S.M., Garai, Kanchan, Rath, Nigam P., Yan, Ping, Cirrito, John R., Cairns, Nigel J., Lee, Jin-Moo, Sharma, Vijay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4372081/
https://www.ncbi.nlm.nih.gov/pubmed/25003699
http://dx.doi.org/10.1021/ol501264q
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author Sundaram, G.S.M.
Garai, Kanchan
Rath, Nigam P.
Yan, Ping
Cirrito, John R.
Cairns, Nigel J.
Lee, Jin-Moo
Sharma, Vijay
author_facet Sundaram, G.S.M.
Garai, Kanchan
Rath, Nigam P.
Yan, Ping
Cirrito, John R.
Cairns, Nigel J.
Lee, Jin-Moo
Sharma, Vijay
author_sort Sundaram, G.S.M.
collection PubMed
description [Image: see text] Emerging paradigms mandate discovery of imaging agents for diagnosing Alzheimer’s disease (AD) prior to appearance of clinical symptoms. To accomplish this objective, a novel heterocyclic molecule (4) was synthesized and validated as Aβ targeted probe. The agent shows labeling of numerous diffuse Aβ plaques in confirmed AD human brain tissues and traverses the blood–brain barrier to enable labeling of parenchymal Aβ plaques in live mice (APP(±)/PS1(±)) brains.
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spelling pubmed-43720812015-07-08 Characterization of a Brain Permeant Fluorescent Molecule and Visualization of Aβ Parenchymal Plaques, Using Real-Time Multiphoton Imaging in Transgenic Mice Sundaram, G.S.M. Garai, Kanchan Rath, Nigam P. Yan, Ping Cirrito, John R. Cairns, Nigel J. Lee, Jin-Moo Sharma, Vijay Org Lett [Image: see text] Emerging paradigms mandate discovery of imaging agents for diagnosing Alzheimer’s disease (AD) prior to appearance of clinical symptoms. To accomplish this objective, a novel heterocyclic molecule (4) was synthesized and validated as Aβ targeted probe. The agent shows labeling of numerous diffuse Aβ plaques in confirmed AD human brain tissues and traverses the blood–brain barrier to enable labeling of parenchymal Aβ plaques in live mice (APP(±)/PS1(±)) brains. American Chemical Society 2014-07-08 2014-07-18 /pmc/articles/PMC4372081/ /pubmed/25003699 http://dx.doi.org/10.1021/ol501264q Text en Copyright © 2014 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Sundaram, G.S.M.
Garai, Kanchan
Rath, Nigam P.
Yan, Ping
Cirrito, John R.
Cairns, Nigel J.
Lee, Jin-Moo
Sharma, Vijay
Characterization of a Brain Permeant Fluorescent Molecule and Visualization of Aβ Parenchymal Plaques, Using Real-Time Multiphoton Imaging in Transgenic Mice
title Characterization of a Brain Permeant Fluorescent Molecule and Visualization of Aβ Parenchymal Plaques, Using Real-Time Multiphoton Imaging in Transgenic Mice
title_full Characterization of a Brain Permeant Fluorescent Molecule and Visualization of Aβ Parenchymal Plaques, Using Real-Time Multiphoton Imaging in Transgenic Mice
title_fullStr Characterization of a Brain Permeant Fluorescent Molecule and Visualization of Aβ Parenchymal Plaques, Using Real-Time Multiphoton Imaging in Transgenic Mice
title_full_unstemmed Characterization of a Brain Permeant Fluorescent Molecule and Visualization of Aβ Parenchymal Plaques, Using Real-Time Multiphoton Imaging in Transgenic Mice
title_short Characterization of a Brain Permeant Fluorescent Molecule and Visualization of Aβ Parenchymal Plaques, Using Real-Time Multiphoton Imaging in Transgenic Mice
title_sort characterization of a brain permeant fluorescent molecule and visualization of aβ parenchymal plaques, using real-time multiphoton imaging in transgenic mice
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4372081/
https://www.ncbi.nlm.nih.gov/pubmed/25003699
http://dx.doi.org/10.1021/ol501264q
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