Mechanistic and Kinetic Studies of the Direct Alkylation of Benzylic Amines: A Formal C(sp(3))–H Activation Proceeds Actually via a C(sp(2))–H Activation Pathway

[Image: see text] Mechanistic investigations of a Rh(I)-catalyzed direct C–H alkylation of benzylic amines with alkenes, formally an C(sp(3))–H activation, reveal this reaction to proceed via imine intermediates and, hence, via C(sp(2))–H activation. The reaction shows a primary kinetic isotope effe...

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Detalles Bibliográficos
Autores principales: Pollice, Robert, Dastbaravardeh, Navid, Marquise, Nada, Mihovilovic, Marko D., Schnürch, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4372103/
https://www.ncbi.nlm.nih.gov/pubmed/25838971
http://dx.doi.org/10.1021/cs501924c

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4372103/
https://www.ncbi.nlm.nih.gov/pubmed/25838971
http://dx.doi.org/10.1021/cs501924c

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