Diazo Groups Endure Metabolism and Enable Chemoselectivity in Cellulo

[Image: see text] We introduce a stabilized diazo group as a reporter for chemical biology. ManDiaz, which is a diazo derivative of N-acetylmannosamine, is found to endure cellular metabolism and label the surface of a mammalian cell. There its diazo group can undergo a 1,3-dipolar cycloaddition wit...

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Detalles Bibliográficos
Autores principales: Andersen, Kristen A., Aronoff, Matthew R., McGrath, Nicholas A., Raines, Ronald T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2015
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4372190/
https://www.ncbi.nlm.nih.gov/pubmed/25658416
http://dx.doi.org/10.1021/ja5095815

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4372190/
https://www.ncbi.nlm.nih.gov/pubmed/25658416
http://dx.doi.org/10.1021/ja5095815

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