The cAMP sensors, EPAC1 and EPAC2, display distinct subcellular distributions despite sharing a common nuclear pore localisation signal

We have identified a conserved nuclear pore localisation signal (NPLS; amino acids 764–838 of EPAC1) in the catalytic domains of the cAMP-sensors, EPAC1 and EPAC2A. Consequently, EPAC1 is mainly localised to the nuclear pore complex in HEK293T cells where it becomes activated following stimulation w...

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Detalles Bibliográficos
Autores principales: Parnell, Euan, Smith, Brian O., Yarwood, Stephen J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science Ltd 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4372255/
https://www.ncbi.nlm.nih.gov/pubmed/25683912
http://dx.doi.org/10.1016/j.cellsig.2015.02.009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4372255/
https://www.ncbi.nlm.nih.gov/pubmed/25683912
http://dx.doi.org/10.1016/j.cellsig.2015.02.009

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