Global Analysis of Protein N-Myristoylation and Exploration of N-Myristoyltransferase as a Drug Target in the Neglected Human Pathogen Leishmania donovani

N-Myristoyltransferase (NMT) modulates protein function through the attachment of the lipid myristate to the N terminus of target proteins, and is a promising drug target in eukaryotic parasites such as Leishmania donovani. Only a small number of NMT substrates have been characterized in Leishmania,...

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Detalles Bibliográficos
Autores principales: Wright, Megan H., Paape, Daniel, Storck, Elisabeth M., Serwa, Remigiusz A., Smith, Deborah F., Tate, Edward W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4372256/
https://www.ncbi.nlm.nih.gov/pubmed/25728269
http://dx.doi.org/10.1016/j.chembiol.2015.01.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4372256/
https://www.ncbi.nlm.nih.gov/pubmed/25728269
http://dx.doi.org/10.1016/j.chembiol.2015.01.003

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