Cargando…

Global Analysis of Protein N-Myristoylation and Exploration of N-Myristoyltransferase as a Drug Target in the Neglected Human Pathogen Leishmania donovani

N-Myristoyltransferase (NMT) modulates protein function through the attachment of the lipid myristate to the N terminus of target proteins, and is a promising drug target in eukaryotic parasites such as Leishmania donovani. Only a small number of NMT substrates have been characterized in Leishmania,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wright, Megan H., Paape, Daniel, Storck, Elisabeth M., Serwa, Remigiusz A., Smith, Deborah F., Tate, Edward W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4372256/ https://www.ncbi.nlm.nih.gov/pubmed/25728269 http://dx.doi.org/10.1016/j.chembiol.2015.01.003

Ejemplares similares

Discovery of high affinity inhibitors of Leishmania donovani N-myristoyltransferase
por: Rackham, Mark D., et al.
Publicado: (2015)

Structure-Based Design of Potent and Selective LeishmaniaN-Myristoyltransferase Inhibitors
por: Hutton, Jennie A., et al.
Publicado: (2014)

Pharmacological Validation of N-Myristoyltransferase as a Drug Target in Leishmania donovani
por: Corpas-Lopez, Victoriano, et al.
Publicado: (2018)

Novel Thienopyrimidine Inhibitors of Leishmania N-Myristoyltransferase with On-Target Activity in Intracellular Amastigotes
por: Bell, Andrew S., et al.
Publicado: (2020)

Whole Proteome Profiling of N-Myristoyltransferase Activity and Inhibition Using Sortase A
por: Goya Grocin, Andrea, et al.
Publicado: (2019)

N-Myristoyltransferase from Leishmania donovani: Structural and Functional Characterisation of a Potential Drug Target for Visceral Leishmaniasis
por: Brannigan, James A., et al.
Publicado: (2010)

Global profiling of co- and post-translationally N-myristoylated proteomes in human cells
por: Thinon, Emmanuelle, et al.
Publicado: (2014)

Genetic validation of Leishmania genes essential for amastigote survival in vivo using N-myristoyltransferase as a model
por: Paape, Daniel, et al.
Publicado: (2020)

Myristoyl-CoA:protein N-myristoyltransferase depletion in trypanosomes causes avirulence and endocytic defects
por: Price, Helen P., et al.
Publicado: (2010)

High-resolution snapshots of human N-myristoyltransferase in action illuminate a mechanism promoting N-terminal Lys and Gly myristoylation
por: Dian, Cyril, et al.
Publicado: (2020)

Using a Non-Image-Based Medium-Throughput Assay for Screening Compounds Targeting N-myristoylation in Intracellular Leishmania Amastigotes
por: Paape, Daniel, et al.
Publicado: (2014)

Myristic acid auxotrophy caused by mutation of S. cerevisiae myristoyl- CoA:protein N-myristoyltransferase
Publicado: (1991)

Biochemical Characterization of Bovine Brain Myristoyl-CoA:Protein N-Myristoyltransferase Type 2
por: Selvakumar, Ponniah, et al.
Publicado: (2009)

Diverse modes of binding in structures of Leishmania major N-myristoyltransferase with selective inhibitors
por: Brannigan, James A., et al.
Publicado: (2014)

Myristoylation profiling in human cells and zebrafish
por: Broncel, Malgorzata, et al.
Publicado: (2015)

Inhibition of vaccinia virus L1 N-myristoylation by the host N-myristoyltransferase inhibitor IMP-1088 generates non-infectious virions defective in cell entry
por: Priyamvada, Lalita, et al.
Publicado: (2022)

Validation and Invalidation of Chemical Probes for the Human N-myristoyltransferases
por: Kallemeijn, Wouter W., et al.
Publicado: (2019)

Structure-guided optimization of quinoline inhibitors of Plasmodium N-myristoyltransferase
por: Goncalves, Victor, et al.
Publicado: (2016)

Discovery of pyridyl-based inhibitors of Plasmodium falciparum N-myristoyltransferase
por: Yu, Zhiyong, et al.
Publicado: (2015)

Profiling of myristoylation in Toxoplasma gondii reveals an N-myristoylated protein important for host cell penetration
por: Broncel, Malgorzata, et al.
Publicado: (2020)

Peptidomimetic inhibitors of N-myristoyltransferase from human malaria and leishmaniasis parasites
por: Olaleye, Tayo O., et al.
Publicado: (2014)

Wheat pathogen Zymoseptoria tritici N-myristoyltransferase inhibitors: on-target antifungal activity and an unusual metabolic defense mechanism
por: Fedoryshchak, Roman O., et al.
Publicado: (2020)

The role of N-myristoyltransferase 1 in tumour development
por: Wang, Hong, et al.
Publicado: (2023)

Exploring Novel N-Myristoyltransferase Inhibitors: A Molecular Dynamics Simulation Approach
por: Khalil, Ruqaiya, et al.
Publicado: (2019)

N-Myristoyltransferase Is a Cell Wall Target in Aspergillus fumigatus
por: Fang, Wenxia, et al.
Publicado: (2015)

Structure-Guided Identification of Resistance Breaking Antimalarial N‑Myristoyltransferase Inhibitors
por: Schlott, Anja C., et al.
Publicado: (2019)

Biochemical and genetic characterization of Trypanosoma cruzi N-myristoyltransferase
por: Roberts, Adam J., et al.
Publicado: (2014)

QSAR Study of N-Myristoyltransferase Inhibitors of Antimalarial Agents
por: Santos-Garcia, Letícia, et al.
Publicado: (2018)

N-Myristoyltransferase Inhibition Induces ER-Stress, Cell Cycle Arrest, and Apoptosis in Cancer Cells
por: Thinon, Emmanuelle, et al.
Publicado: (2016)

N-Myristoyltransferase inhibitors as new leads to treat sleeping sickness
por: Frearson, Julie A., et al.
Publicado: (2010)

Discovery of Novel and Ligand-Efficient Inhibitors of Plasmodium falciparum and Plasmodium vivaxN-Myristoyltransferase
por: Rackham, Mark D., et al.
Publicado: (2012)

Targeting N-myristoylation for therapy of B-cell lymphomas
por: Beauchamp, Erwan, et al.
Publicado: (2020)

Prediction of N-myristoylation modification of proteins by SVM
por: Cao, Wei, et al.
Publicado: (2011)

Selective Inhibitors of Protozoan Protein N-myristoyltransferases as Starting Points for Tropical Disease Medicinal Chemistry Programs
por: Bell, Andrew S., et al.
Publicado: (2012)

Design and Synthesis of Brain Penetrant Trypanocidal N-Myristoyltransferase Inhibitors
por: Bayliss, Tracy, et al.
Publicado: (2017)

Inhibition of N‐myristoyltransferase1 affects dengue virus replication
por: Suwanmanee, San, et al.
Publicado: (2019)

Inhibitor Trapping in N-Myristoyltransferases as a Mechanism for Drug Potency
por: Spassov, Danislav S., et al.
Publicado: (2023)

Detecting N-myristoylation and S-acylation of host and pathogen proteins in plants using click chemistry
por: Boyle, Patrick C., et al.
Publicado: (2016)

LEISHMANIA DONOVANI IN THE PERIPHERAL BLOOD
por: Young, Charles W., et al.
Publicado: (1923)

Mouse Stbd1 is N-myristoylated and affects ER–mitochondria association and mitochondrial morphology
por: Demetriadou, Anthi, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_18hrcnmhh15djqe8p0a6bgk8oe