DNA demethylation by 5-aza-2′-deoxycytidine is imprinted, targeted to euchromatin, and has limited transcriptional consequences

BACKGROUND: DNA methylation can be abnormally regulated in human disease and associated with effects on gene transcription that appear to be causally related to pathogenesis. The potential to use pharmacological agents that reverse this dysregulation is therefore an attractive possibility. To test h...

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Detalles Bibliográficos
Autores principales: Ramos, María-Paz, Wijetunga, Neil Ari, McLellan, Andrew S, Suzuki, Masako, Greally, John M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4372267/
https://www.ncbi.nlm.nih.gov/pubmed/25806086
http://dx.doi.org/10.1186/s13072-015-0004-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4372267/
https://www.ncbi.nlm.nih.gov/pubmed/25806086
http://dx.doi.org/10.1186/s13072-015-0004-x

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