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MD-2 Determinants of Nickel and Cobalt-Mediated Activation of Human TLR4
Recent findings unexpectedly revealed that human TLR4 can be directly activated by nickel ions. This activation is due to the coordination of nickel by a cluster of histidine residues on the ectodomain of human TLR4, which is absent in most other species. We aimed to elucidate the role of MD-2 in th...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4372398/ https://www.ncbi.nlm.nih.gov/pubmed/25803856 http://dx.doi.org/10.1371/journal.pone.0120583 |