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β-HPV 5 and 8 E6 Disrupt Homology Dependent Double Strand Break Repair by Attenuating BRCA1 and BRCA2 Expression and Foci Formation

Recent work has explored a putative role for the E6 protein from some β-human papillomavirus genus (β-HPVs) in the development of non-melanoma skin cancers, specifically β-HPV 5 and 8 E6. Because these viruses are not required for tumor maintenance, they are hypothesized to act as co-factors that en...

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Detalles Bibliográficos
Autores principales: Wallace, Nicholas A., Robinson, Kristin, Howie, Heather L., Galloway, Denise A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4372404/
https://www.ncbi.nlm.nih.gov/pubmed/25803638
http://dx.doi.org/10.1371/journal.ppat.1004687