Opposite Phenotypes of Muscle Strength and Locomotor Function in Mouse Models of Partial Trisomy and Monosomy 21 for the Proximal Hspa13-App Region

The trisomy of human chromosome 21 (Hsa21), which causes Down syndrome (DS), is the most common viable human aneuploidy. In contrast to trisomy, the complete monosomy (M21) of Hsa21 is lethal, and only partial monosomy or mosaic monosomy of Hsa21 is seen. Both conditions lead to variable physiologic...

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Detalles Bibliográficos
Autores principales: Brault, Véronique, Duchon, Arnaud, Romestaing, Caroline, Sahun, Ignasi, Pothion, Stéphanie, Karout, Mona, Borel, Christelle, Dembele, Doulaye, Bizot, Jean-Charles, Messaddeq, Nadia, Sharp, Andrew J., Roussel, Damien, Antonarakis, Stylianos E, Dierssen, Mara, Hérault, Yann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4372517/
https://www.ncbi.nlm.nih.gov/pubmed/25803843
http://dx.doi.org/10.1371/journal.pgen.1005062

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4372517/
https://www.ncbi.nlm.nih.gov/pubmed/25803843
http://dx.doi.org/10.1371/journal.pgen.1005062

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