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Splice Variants of Activation Induced Deaminase (AID) Do Not Affect the Efficiency of Class Switch Recombination in Murine CH12F3 Cells

Activation Induced Deaminase (AID) triggers the antigen-driven antibody diversification processes through its ability to edit DNA. AID dependent DNA damage is also the cause of genetic alterations often found in mature B cell tumors. A number of splice variants of AID have been identified, for which...

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Detalles Bibliográficos
Autores principales: Sala, Cesare, Mattiuz, Giorgio, Pietrobono, Silvia, Chicca, Andrea, Conticello, Silvestro G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4372541/
https://www.ncbi.nlm.nih.gov/pubmed/25803053
http://dx.doi.org/10.1371/journal.pone.0121719