Efficacy of a Parainfluenza Virus 5 (PIV5)-Based H7N9 Vaccine in Mice and Guinea Pigs: Antibody Titer towards HA Was Not a Good Indicator for Protection

H7N9 has caused fatal infections in humans. A safe and effective vaccine is the best way to prevent large-scale outbreaks in the human population. Parainfluenza virus 5 (PIV5), an avirulent paramyxovirus, is a promising vaccine vector. In this work, we generated a recombinant PIV5 expressing the HA...

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Detalles Bibliográficos
Autores principales: Li, Zhuo, Gabbard, Jon D., Johnson, Scott, Dlugolenski, Daniel, Phan, Shannon, Tompkins, S. Mark, He, Biao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4372596/
https://www.ncbi.nlm.nih.gov/pubmed/25803697
http://dx.doi.org/10.1371/journal.pone.0120355

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4372596/
https://www.ncbi.nlm.nih.gov/pubmed/25803697
http://dx.doi.org/10.1371/journal.pone.0120355

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