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The loss of Tm7sf gene accelerates skin papilloma formation in mice

The 3β-hydroxysterol Δ14-reductase, encoded by the Tm7sf2 gene, is an enzyme involved in cholesterol biosynthesis. Cholesterol and its derivatives control epidermal barrier integrity and are protective against environmental insults. To determine the role of the gene in skin cholesterol homeostasis,...

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Detalles Bibliográficos
Autores principales: Bellezza, I., Gatticchi, L., Sordo, R. del, Peirce, M. J., Sidoni, A., Roberti, R., Minelli, A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4372794/
https://www.ncbi.nlm.nih.gov/pubmed/25804527
http://dx.doi.org/10.1038/srep09471