The toxicity of tau in Alzheimer disease: turnover, targets and potential therapeutics

It has been almost 25 years since the initial discovery that tau was the primary component of the neurofibrillary tangles (NFTs) in Alzheimer disease (AD) brain. Although AD is defined by both β-amyloid (Aβ) pathology (Aβ plaques) and tau pathology (NFTs), whether or not tau played a critical role i...

Descripción completa

Detalles Bibliográficos
Autores principales: Pritchard, Susanne M, Dolan, Philip J, Vitkus, Alisa, Johnson, Gail VW
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2011
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4373356/
https://www.ncbi.nlm.nih.gov/pubmed/21348938
http://dx.doi.org/10.1111/j.1582-4934.2011.01273.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4373356/
https://www.ncbi.nlm.nih.gov/pubmed/21348938
http://dx.doi.org/10.1111/j.1582-4934.2011.01273.x

Ejemplares similares