Cargando…
Aberrant methylation and associated transcriptional mobilization of Alu elements contributes to genomic instability in hypoxia
Hypoxia is an integral part of tumorigenesis and contributes extensively to the neoplastic phenotype including drug resistance and genomic instability. It has also been reported that hypoxia results in global demethylation. Because a majority of the cytosine-phosphate-guanine (CpG) islands are found...
| Autores principales: | , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Blackwell Publishing Ltd
2010
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4373486/ https://www.ncbi.nlm.nih.gov/pubmed/19508390 http://dx.doi.org/10.1111/j.1582-4934.2009.00792.x |