Multiplicity of Steady States in Glycolysis and Shift of Metabolic State in Cultured Mammalian Cells

Cultured mammalian cells exhibit elevated glycolysis flux and high lactate production. In the industrial bioprocesses for biotherapeutic protein production, glucose is supplemented to the culture medium to sustain continued cell growth resulting in the accumulation of lactate to high levels. In such...

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Detalles Bibliográficos
Autores principales: Mulukutla, Bhanu Chandra, Yongky, Andrew, Grimm, Simon, Daoutidis, Prodromos, Hu, Wei-Shou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4373774/
https://www.ncbi.nlm.nih.gov/pubmed/25806512
http://dx.doi.org/10.1371/journal.pone.0121561

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4373774/
https://www.ncbi.nlm.nih.gov/pubmed/25806512
http://dx.doi.org/10.1371/journal.pone.0121561

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