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Multiplicity of Steady States in Glycolysis and Shift of Metabolic State in Cultured Mammalian Cells
Cultured mammalian cells exhibit elevated glycolysis flux and high lactate production. In the industrial bioprocesses for biotherapeutic protein production, glucose is supplemented to the culture medium to sustain continued cell growth resulting in the accumulation of lactate to high levels. In such...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4373774/ https://www.ncbi.nlm.nih.gov/pubmed/25806512 http://dx.doi.org/10.1371/journal.pone.0121561 |