Clonal Evolution Revealed by Whole Genome Sequencing in a Case of Primary Myelofibrosis Transformed to Secondary Acute Myeloid Leukemia

Clonal architecture in myeloproliferative neoplasms (MPNs) is poorly understood. Here we report genomic analyses of a patient with primary myelofibrosis (PMF) transformed to secondary acute myeloid leukemia (sAML). Whole genome sequencing (WGS) was performed on PMF and sAML diagnosis samples, with s...

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Detalles Bibliográficos
Autores principales: Engle, Elizabeth K., Fisher, Daniel A.C., Miller, Christopher A., McLellan, Michael D., Fulton, Robert S., Moore, Deborah M., Wilson, Richard K., Ley, Timothy J., Oh, Stephen T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4374044/
https://www.ncbi.nlm.nih.gov/pubmed/25252869
http://dx.doi.org/10.1038/leu.2014.289

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4374044/
https://www.ncbi.nlm.nih.gov/pubmed/25252869
http://dx.doi.org/10.1038/leu.2014.289

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