TopBP1 Interacts with BLM to Maintain Genome Stability but Is Dispensable for Preventing BLM Degradation

The Bloom syndrome helicase BLM and topoisomerase-IIβ-binding protein 1 (TopBP1) are key regulators of genome stability. It was recently proposed that BLM phosphorylation on Ser338 mediates its interaction with TopBP1, to protect BLM from ubiquitylation and degradation (Wang et al., 2013). Here, we...

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Detalles Bibliográficos
Autores principales: Blackford, Andrew N., Nieminuszczy, Jadwiga, Schwab, Rebekka A., Galanty, Yaron, Jackson, Stephen P., Niedzwiedz, Wojciech
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2015
Materias:
Matters Arising
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4374139/
https://www.ncbi.nlm.nih.gov/pubmed/25794620
http://dx.doi.org/10.1016/j.molcel.2015.02.012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4374139/
https://www.ncbi.nlm.nih.gov/pubmed/25794620
http://dx.doi.org/10.1016/j.molcel.2015.02.012

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