Lagging strand replication shapes the mutational landscape of the genome

The origin of mutations is central to understanding evolution and of key relevance to health. Variation occurs non-randomly across the genome, and mechanisms for this remain to be defined. Here, we report that the 5′-ends of Okazaki fragments have significantly elevated levels of nucleotide substitu...

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Detalles Bibliográficos
Autores principales: Reijns, Martin A. M., Kemp, Harriet, Ding, James, de Procé, Sophie Marion, Jackson, Andrew P., Taylor, Martin S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4374164/
https://www.ncbi.nlm.nih.gov/pubmed/25624100
http://dx.doi.org/10.1038/nature14183

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4374164/
https://www.ncbi.nlm.nih.gov/pubmed/25624100
http://dx.doi.org/10.1038/nature14183

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