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Lagging strand replication shapes the mutational landscape of the genome

The origin of mutations is central to understanding evolution and of key relevance to health. Variation occurs non-randomly across the genome, and mechanisms for this remain to be defined. Here, we report that the 5′-ends of Okazaki fragments have significantly elevated levels of nucleotide substitu...

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Detalles Bibliográficos
Autores principales:	Reijns, Martin A. M., Kemp, Harriet, Ding, James, de Procé, Sophie Marion, Jackson, Andrew P., Taylor, Martin S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4374164/ https://www.ncbi.nlm.nih.gov/pubmed/25624100 http://dx.doi.org/10.1038/nature14183

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