Myocyte enhancer factor (MEF)-2 plays essential roles in T-cell transformation associated with HTLV-1 infection by stabilizing complex between Tax and CREB

BACKGROUND: The exact molecular mechanisms regarding HTLV-1 Tax-mediated viral gene expression and CD4 T-cell transformation have yet to be fully delineated. Herein, utilizing virus-infected primary CD4(+) T cells and the virus-producing cell line, MT-2, we describe the involvement and regulation of...

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Detalles Bibliográficos
Autores principales: Jain, Pooja, Lavorgna, Alfonso, Sehgal, Mohit, Gao, Linlin, Ginwala, Rashida, Sagar, Divya, Harhaj, Edward W, Khan, Zafar K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4374383/
https://www.ncbi.nlm.nih.gov/pubmed/25809782
http://dx.doi.org/10.1186/s12977-015-0140-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4374383/
https://www.ncbi.nlm.nih.gov/pubmed/25809782
http://dx.doi.org/10.1186/s12977-015-0140-1

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