Cargando…

Myocyte enhancer factor (MEF)-2 plays essential roles in T-cell transformation associated with HTLV-1 infection by stabilizing complex between Tax and CREB

BACKGROUND: The exact molecular mechanisms regarding HTLV-1 Tax-mediated viral gene expression and CD4 T-cell transformation have yet to be fully delineated. Herein, utilizing virus-infected primary CD4(+) T cells and the virus-producing cell line, MT-2, we describe the involvement and regulation of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jain, Pooja, Lavorgna, Alfonso, Sehgal, Mohit, Gao, Linlin, Ginwala, Rashida, Sagar, Divya, Harhaj, Edward W, Khan, Zafar K
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4374383/ https://www.ncbi.nlm.nih.gov/pubmed/25809782 http://dx.doi.org/10.1186/s12977-015-0140-1

Ejemplares similares

Regulation of HTLV-1 Tax Stability, Cellular Trafficking and NF-κB Activation by the Ubiquitin-Proteasome Pathway
por: Lavorgna, Alfonso, et al.
Publicado: (2014)

STAMBPL1 is a deubiquitinating enzyme that regulates HTLV-I Tax subcellular localization and NF-kB activation
por: Lavorgna, Alfonso, et al.
Publicado: (2011)

Mechanisms of Oncogenesis by HTLV-1 Tax
por: Mohanty, Suchitra, et al.
Publicado: (2020)

A Critical Role for IL-17RB Signaling in HTLV-1 Tax-Induced NF-κB Activation and T-Cell Transformation
por: Lavorgna, Alfonso, et al.
Publicado: (2014)

A critical role for IL-17RB signaling in HTLV-1 tax-induced NF-κB activation and T-cell transformation
por: Lavorgna, Alfonso, et al.
Publicado: (2015)

The E3/E4 ubiquitin conjugation factor UBE4B interacts with and ubiquitinates the HTLV-1 Tax oncoprotein to promote NF-κB activation
por: Mohanty, Suchitra, et al.
Publicado: (2020)

Involvement of HTLV-I Tax and CREB in aneuploidy: a bioinformatics approach
por: de la Fuente, Cynthia, et al.
Publicado: (2006)

MEF-2 isoforms' (A-D) roles in development and tumorigenesis
por: Madugula, Kiran, et al.
Publicado: (2019)

Impact of dendritic cells and adjuvant on the in vivo immunogenicity of HTLV-1 Tax 11-19 epitope in hybrid HLA-A2.1/DTR transgenic mice
por: Sagar, Divya, et al.
Publicado: (2014)

Regulation of human T-cell leukemia virus type 1 antisense promoter by myocyte enhancer factor-2C in the context of adult T-cell leukemia and lymphoma
por: Madugula, Kiran K., et al.
Publicado: (2022)

HTLV-I Tax inhibits innate antiviral signaling via NF-κB-dependent induction of SOCS1
por: Charoenthongtrakul, Soratree, et al.
Publicado: (2011)

The human T-cell leukemia virus type I (HTLV-I) oncoprotein Tax promotes persistent NF-κB activation by blocking the phosphorylation of the adaptor molecule TAX1BP
por: Shembade, Noula, et al.
Publicado: (2011)

Distinct activities of HTLV-1 Tax1 from HTLV-2 Tax2 play key roles in pathogenesis
por: Fujii, Masahiro, et al.
Publicado: (2011)

Transcriptome analysis of HTLV-1-infected cells in comparison to the normal and Tax-expressing T cells
por: Singh, Shruti, et al.
Publicado: (2011)

In vivo immunogenicity of Tax (11-19) epitope in HLA-A2/DTR transgenic mice: implication for dendritic cell-based anti-HTLV-1 vaccine.
por: Sagar, Divya, et al.
Publicado: (2015)

Modulation of dendritic cell functions by HTLV-1 with DCs able to direct the presentation of Tax through infected T cells, live virus, and the Tax protein
por: Manuel, Sharrón L, et al.
Publicado: (2011)

HTLV-1 Tax Stabilizes MCL-1 via TRAF6-Dependent K63-Linked Polyubiquitination to Promote Cell Survival and Transformation
por: Choi, Young Bong, et al.
Publicado: (2014)

Potential Role of Flavonoids in Treating Chronic Inflammatory Diseases with a Special Focus on the Anti-Inflammatory Activity of Apigenin
por: Ginwala, Rashida, et al.
Publicado: (2019)

The HTLV-1 Tax interactome
por: Boxus, Mathieu, et al.
Publicado: (2008)

HTLV-1 Tax Mediated Downregulation of miRNAs Associated with Chromatin Remodeling Factors in T Cells with Stably Integrated Viral Promoter
por: Rahman, Saifur, et al.
Publicado: (2012)

HTLV-1 Tax mediated downregulation of miRNAs associated with chromatin remodeling factors in T cells with stably integrated viral promoter
por: Rahman, Saifur, et al.
Publicado: (2014)

SUV39H1 interacts with HTLV-1 Tax and abrogates Tax transactivation of HTLV-1 LTR
por: Kamoi, Koju, et al.
Publicado: (2006)

Targeted multi-epitope therapeutic vaccine for the treatment of invasive glioblastoma multiforme
por: Huang, Xiaofang, et al.
Publicado: (2015)

HTLV-1 Tax: centrosome amplification and cancer
por: Pumfery, Anne, et al.
Publicado: (2006)

The importance of ubiquitination and sumoylation on the transforming activity of HTLV Tax-1 and Tax-2
por: Zane, Linda, et al.
Publicado: (2012)

Distinct functions of HTLV-1 Tax1 from HTLV-2 Tax2 contribute key roles to viral pathogenesis
por: Higuchi, Masaya, et al.
Publicado: (2009)

The HTLV-1 Tax Protein Cooperates with Phosphorylated CREB, TORC2, and p300 to Activate CRE-Dependent Cyclin D1 Transcription
por: Kim, Young-Mi, et al.
Publicado: (2010)

Antibody blockade of CLEC12A delays EAE onset and attenuates disease severity by impairing myeloid cell CNS infiltration and restoring positive immunity
por: Sagar, Divya, et al.
Publicado: (2017)

Mechanisms of Innate Immune Sensing of HTLV-1 and Viral Immune Evasion
por: Mohanty, Suchitra, et al.
Publicado: (2023)

Lack of recall response to Tax in ATL and HAM/TSP patients but not in asymptomatic carriers of human T-cell leukemia virus type 1
por: Manuel, Sharrón L, et al.
Publicado: (2014)

Move or Die: the Fate of the Tax Oncoprotein of HTLV-1
por: Lodewick, Julie, et al.
Publicado: (2011)

Expression and purification of the HTLV-1 transforming protein Tax
por: Evans, Whitney, et al.
Publicado: (2011)

Induction of galectin-1 expression by HTLV-I Tax and its impact on HTLV-I infectivity
por: Gauthier, Sonia, et al.
Publicado: (2008)

Expression of the HBZ and tax genes of HTLV-1in infective dermatitis associated with HTLV-I (IDH)
por: Batista, Everton S, et al.
Publicado: (2011)

Transcription Regulation of Tceal7 by the Triple Complex of Mef2c, Creb1 and Myod
por: Xiong, Zhenzhen, et al.
Publicado: (2022)

A specificity map for HTLV-1 Tax/PDZ interactions
por: Blibek, Karim, et al.
Publicado: (2011)

Transformation of human embryonic stem cells by HTLV-1 Tax
por: Zane, Linda, et al.
Publicado: (2011)

An interaction map for HTLV-1 Tax and PDZ-containing proteins
por: Blibek, Karim, et al.
Publicado: (2014)

HTLV-1 Tax targets centrosomal Cep63 protein
por: Martin, Emilie, et al.
Publicado: (2015)

Highlights on distinctive structural and functional properties of HTLV Tax proteins
por: Romanelli, Maria Grazia, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_k4i8vu55r6ser9fjtg136bftaj