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SULF2 overexpression positively regulates tumorigenicity of human prostate cancer cells

BACKGROUND: SULF2 is a 6-O-endosulfatase which removes 6-O sulfate residues from N-glucosamine present on heparan sulfate (HS). The sulfation pattern of HS influences signaling events mediated by heparan sulfate proteoglycans (HSPGs) located on cell surface, which are critical for the interactions w...

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Detalles Bibliográficos
Autores principales: Vicente, Carolina M, Lima, Marcelo A, Nader, Helena B, Toma, Leny
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4374423/
https://www.ncbi.nlm.nih.gov/pubmed/25887999
http://dx.doi.org/10.1186/s13046-015-0141-x