Intermittent Hypoxia Selects for Genotypes and Phenotypes That Increase Survival, Invasion, and Therapy Resistance

Hypoxia in tumors correlates with greater risk of metastases, increased invasiveness, and resistance to systemic and radiation therapy. The evolutionary dynamics that links specific adaptations to hypoxia with these observed tumor properties have not been well investigated. While some tumor populati...

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Detalles Bibliográficos
Autores principales: Verduzco, Daniel, Lloyd, Mark, Xu, Liping, Ibrahim-Hashim, Arig, Balagurunathan, Yoganand, Gatenby, Robert A., Gillies, Robert J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4374837/
https://www.ncbi.nlm.nih.gov/pubmed/25811878
http://dx.doi.org/10.1371/journal.pone.0120958

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4374837/
https://www.ncbi.nlm.nih.gov/pubmed/25811878
http://dx.doi.org/10.1371/journal.pone.0120958

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